athlete taking a nitric oxide supplement

Best Nitric Oxide Boosting Supplements (and Why Most Pre-Workouts Fail)

April 9, 2018 Published by

These days, pre-workout and nitric oxide boosting supplements all seem to be carbon copies of one another. Don’t believe me? Go to your local supplement store and just browse the pre-workout section for a bit; you’ll notice that each company puts out essentially the same pre-workout formula with minimal difference in both ingredient selection and dose.

Unfortunately, many modern pre-workouts are ineffective garbage that gives you a slight rush of ‘energy’ from stimulants that are comparable to methamphetamine. It’s no wonder some people feel like certain pre-workouts “work”.

You could achieve a similar effect by chugging a pot of coffee (and saving your hard-earned cash).

For those who are unaware, pretty much anything that has stimulating properties on your nervous system is going to constrict blood vessels and reduce nitric oxide (NO) production.

Make no mistake that having some caffeine in a pre-workout can be useful, but having too many stimulants will rapidly negate the benefits of nitric oxide boosting supplements.

As such, let’s take a deeper look at the science underlying the top nitric oxide boosting supplements. If your goal is to achieve skin-bursting pumps and maximize blood flow while you wreck some iron, you’ve come to the right place.

The Top Nitric Oxide Boosting Supplements

Nitrosigine ®

Nitrosigine is the advancement of ordinary L-arginine that the bodybuilding realm has long yearned for. This supplement is a trademarked form of L-arginine silicate (stabilized by myo-inositol), having far more biological potential than normal L-arginine. After consuming Nitrosigine, users can expect drastic intensifications in nitric oxide levels and muscular pumps.

There are several paths that Nitrosigine works through. Arguably the most important mechanism is altering key nitric oxide synthases (enzymes that help produce NO); nitrosigine also works by turning on cellular receptors such as alpha (2) – adrenergic receptors.

The research-backed advantages of Nitrosigine consist of relaxation and growth of blood vessels, improvement in insulin sensitivity, and greater nutrient delivery to working muscle tissue.


L-Citrulline is an amino acid found generously in the skin of a watermelon. In humans, it is manufactured in the urea cycle; in medical settings, L-citrulline is one biomarker of gastrointestinal (GI) function.

Citrulline is coming to be more trendy in the realm of sports nutrition and muscle building supplements, however, most products use a form known as citrulline malate (which is less potent than pure L-citrulline).

An effective dosage of pure L-citrulline is upwards of six grams ingested before exercise. Therefore, if you see a pre-workout supplement consisting of 2:1 citrulline malate dosed at two grams per serving, you’re only getting less than one gram of L-citrulline (which is far from sufficient).

Studies show that L-citrulline works to enhance NO-dependent cell signaling. Further research demonstrates that supplementing with L-citrulline before a workout can considerably elevate blood arginine levels. Thus, citrulline helps increase the synthesis of arginine metabolites (i.e. ornithine, agmatine, etc.). 

Other advantages of L-citrulline usage consist of:

  • Improves the usage of branched-chain amino acids throughout training
  • Elevates intracellular nitric oxide levels, which promotes better blood flow and muscular pumps
  • Enhances the body’s capacity to eliminate toxins
  • Increases human growth hormone (HGH) secretion, especially after resistance training


Glutathione is a tripeptide (made up of glutamate, glycine, and cysteine) and arguably the most important endogenous antioxidant in humans. This peptide is shown in vast amounts of research to reduce oxidative stress in pretty much every bodily system.

Moreover, recent findings suggest that glutathione is an important regulator of the NO pathway in endothelial tissue. It is best to take in conjunction with L-citrulline as the two ingredients work synergistically to enhance blood flow and expand blood vessels.

Maximize Nitric Oxide Every Training Session with N.O. XT™

N.O. XT jacked factory supplement

We took the initiative to create a pre-workout that contains clinically effective doses of the best nitric oxide boosting supplements; ingredients that are proven to actually enhance pumps and blood flow while you crush the iron. This product is N.O. XT™ – a non-stimulant, nitric-oxide (NO) boosting supplement that will help you maximize every training session.

The three key ingredients in N.O. XT™ are dosed in amounts that will help athletes and gym goers alike achieve greater muscular pumps and optimize nutrient delivery to working muscle tissue.

The versatility of N.O. XT™ makes it stackable with other pre-workouts as well, like NitroSurge and Altius. Rest assured, Nitrosigine®, L-citrulline, and glutathione will take your training and pumps to a level that you’ve never experienced before!

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Elliot Reimers

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